Mark S Freedman Selected Research

teriflunomide

1/2021	Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial.
11/2020	Long-term safety and efficacy of teriflunomide in patients with relapsing multiple sclerosis: Results from the TOWER extension study.
10/2020	Prior treatment status: impact on the efficacy and safety of teriflunomide in multiple sclerosis.
10/2020	COVID-19 in teriflunomide-treated patients with multiple sclerosis.
1/2020	Characterizing lymphocyte counts and infection rates with long-term teriflunomide treatment: Pooled analysis of clinical trials.
8/2019	Long-term outcomes with teriflunomide in patients with clinically isolated syndrome: Results of the TOPIC extension study★★.
1/2019	Efficacy and safety of teriflunomide in Asian patients with relapsing forms of multiple sclerosis: A subgroup analysis of the phase 3 TOWER study.
7/2018	Tolerability and discontinuation rates in teriflunomide-treated patients. A real-world clinical experience.
1/2018	The efficacy of teriflunomide in patients who received prior disease-modifying treatments: Subgroup analyses of the teriflunomide phase 3 TEMSO and TOWER studies.
11/2016	Comparing outcomes from clinical studies of oral disease-modifying therapies (dimethyl fumarate, fingolimod, and teriflunomide) in relapsing MS: Assessing absolute differences using a number needed to treat analysis.

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Mark S Freedman Research Topics

Disease

112	Multiple Sclerosis 05/2022 - 06/2002
22	Relapsing-Remitting Multiple Sclerosis 01/2022 - 01/2008
11	Disease Progression 01/2018 - 02/2003
7	Inflammation (Inflammations) 11/2021 - 04/2010
5	Fatigue 01/2021 - 01/2014
5	Chronic Progressive Multiple Sclerosis 10/2020 - 10/2009
4	Atrophy 02/2021 - 03/2017
4	Infections 10/2020 - 10/2009
4	Demyelinating Diseases (Demyelinating Disease) 09/2012 - 02/2008
3	Optic Neuritis (Retrobulbar Neuritis) 10/2018 - 06/2006
2	Neuromyelitis Optica (Devic's Disease) 12/2021 - 09/2012
2	COVID-19 11/2021 - 10/2020
2	Lymphopenia (Lymphocytopenia) 01/2020 - 03/2016
2	Dizziness (Lightheadedness) 01/2017 - 11/2014
2	Headache (Headaches) 01/2016 - 03/2014
2	Nausea 01/2016 - 10/2011
2	Diarrhea 01/2016 - 10/2011
2	Human Influenza (Influenza) 11/2014 - 08/2013
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2013 - 07/2011
1	Myasthenia Gravis 12/2021
1	Herpes Zoster 07/2021
1	Progressive Multifocal Leukoencephalopathy 01/2021
1	Opportunistic Infections (Opportunistic Infection) 01/2021
1	Severe Acute Respiratory Syndrome 10/2020
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Weight Gain 10/2018
1	Neuroinflammatory Diseases 04/2017
1	Exanthema (Rash) 01/2017
1	Basal Cell Carcinoma (Rodent Ulcer) 03/2016
1	Atrioventricular Block 03/2016
1	Bradycardia 03/2016
1	Bronchiolitis Obliterans Syndrome 01/2016
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2016
1	Hypothyroidism 09/2015
1	Thyroid Diseases (Thyroid Disease) 09/2015
1	Thyrotoxicosis 09/2015
1	Sleep Initiation and Maintenance Disorders (Insomnia) 11/2014
1	Respiratory Tract Infections (Respiratory Tract Infection) 10/2014
1	HIV Infections (HIV Infection) 06/2014

Drug/Important Bio-Agent (IBA)

24	teriflunomideIBA 01/2021 - 10/2011
9	Interferon beta-1b (Betaseron)FDA Link 01/2020 - 08/2007
8	Interferon beta-1a FDA Link 01/2022 - 04/2004
8	GadoliniumIBA 11/2016 - 02/2008
7	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021 - 09/2014
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2014
5	Alemtuzumab (Campath)FDA Link 07/2021 - 07/2013
5	InterferonsIBA 01/2020 - 03/2014
5	AntibodiesIBA 01/2019 - 01/2007
5	Immunologic Factors (Immunomodulators)IBA 01/2018 - 08/2013
4	ponesimodIBA 01/2022 - 11/2014
4	Cladribine FDA LinkGeneric 07/2021 - 03/2014
4	Sphingosine-1-Phosphate ReceptorsIBA 01/2021 - 11/2014
4	Retinaldehyde (Retinal)IBA 10/2018 - 06/2006
4	Alanine Transaminase (SGPT)IBA 01/2016 - 03/2014
3	Complement System Proteins (Complement)IBA 12/2021 - 10/2010
3	Pharmaceutical PreparationsIBA 01/2021 - 04/2004
3	TabletsIBA 01/2021 - 10/2017
3	Therapeutic UsesIBA 01/2016 - 07/2011
3	Interferon-betaIBA 01/2012 - 08/2007
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 01/2016
2	FumaratesIBA 11/2020 - 01/2020
2	diroximel fumarateIBA 11/2020 - 01/2020
2	Vitamin D FDA LinkGeneric 01/2020 - 03/2014
2	Dimethyl FumarateIBA 01/2020 - 11/2016
2	Oligoclonal BandsIBA 01/2018 - 04/2009
2	siponimodIBA 09/2016 - 08/2013
2	Immunoglobulin G (IgG)IBA 11/2015 - 01/2007
2	Rituximab (Mabthera)FDA Link 10/2009 - 08/2008
2	Monoclonal AntibodiesIBA 10/2009 - 08/2008
1	ocrelizumabIBA 01/2022
1	GelsIBA 11/2021
1	Biotin (Vitamin H)FDA Link 12/2020
1	opicinumabIBA 10/2018
1	Busulfan (Busulfex)FDA Link 01/2018
1	Natalizumab (Tysabri)FDA Link 01/2018
1	SodiumIBA 07/2017
1	SaltsIBA 07/2017
1	Abatacept (Orencia)FDA Link 04/2017
1	Proteins (Proteins, Gene)FDA Link 04/2017
1	Minocycline (Cyclops)FDA LinkGeneric 01/2017
1	CotinineIBA 11/2015
1	25-hydroxyvitamin DIBA 08/2014
1	hydroxide ionIBA 08/2014
1	Matrix Metalloproteinases (MMPs)IBA 06/2014

Therapy/Procedure

40	Therapeutics 05/2022 - 05/2004
13	Hematopoietic Stem Cell Transplantation 05/2022 - 08/2010
4	Drug Therapy (Chemotherapy) 01/2020 - 03/2013
3	Transplantation 01/2019 - 04/2010
2	Mesenchymal Stem Cell Transplantation 01/2022 - 04/2010
2	Stem Cell Transplantation 08/2016 - 02/2008
2	Treatment Delay 11/2014 - 11/2009
1	Hematopoietic Stem Cell Mobilization 05/2022
1	Transcranial Magnetic Stimulation 01/2022
1	Critical Care (Surgical Intensive Care) 11/2021
1	Immunotherapy 10/2020
1	Precision Medicine 01/2020
1	Cell Transplantation 01/2019
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/2017
1	Injections 09/2014
1	Subcutaneous Injections 04/2014